Description Principle of Mechanism: Electroportion Transdermal Meso-chip (ETM) perfectly combines meso-chip aqua channel penetration technology and electroporation ion channel transdermal technology. It mainly uses the microneedles in the meso-chip to open the water channels on the skin, and then transport nutrients to the superficial dermis to increase the absorption rate. At the same time, combined with electroporation to penetrate the skin, it can greatly increase the penetration rate and efficiency of liquid molecules, and improve biological efficacy. Technology working principles: Meso-chip aqua channel penetration technology: Through the “volcano-shaped” microcrystals arranged in an array on the meso-chip, open the skin barrier of the epidermis to form micro aqua channels, and the nutrients in the applicator are introduced into the epidermis through the micro water channels to promote the skin Deep absorption. The micro aqua channels can be completely closed naturally within 1-2 hours after the introduction, and the normal barrier structure of the skin surface can be restored. Electroporation ion channel transdermal technology: Electroporation is using Transient electrical pulses to make skin keratinocytes temporarily generate lipid bilayer aqueous channels, so that nutrients can be absorbed through the skin. When the pulsed electric field ends, the lipid bilayer resumes its original disordered orientation, thus closing the aqueous channel. For the skin, as long as the voltage of electroporation exceeds the threshold voltage (the voltage at which the lipid bilayer collapses), reversible transient water pores can be formed in the lipid bilayer between the stratum corneum cells of the skin, thereby greatly Shorten the transdermal time of nutrients and promote the transdermal rate.
